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Life Sciences & Medicine
2018-3-20

Cholesterol leash: key tethering protein found to transport cellular cholesterol

Researchers at Osaka University uncover key mechanistic details that allow cholesterol to be transported within cells

Cholesterol is an essential component of living organisms, but the mechanisms that transport cholesterol inside the cell are poorly understood. Resear...

2018-3-13

Strength in numbers: Worldwide study finds new genetic risk factors for stroke

Researchers in a large multicenter study develop a comprehensive map of genetic risk factors for stroke and lay the groundwork for more individualized approaches to treatment

Stroke is the second leading cause of death worldwide, but its genetic basis is unknown. In a large, multicenter effort, researchers performed a genom...

Life Sciences & Medicine
2018-3-9

Genome does not like to excessively change in male germ cells

Life Sciences & Medicine
2018-3-6

Helpful B cells lend a hand to developing neurons

Researchers at Osaka University identify an immune cell that promotes the growth of neuron-supporting cells in the developing mouse brain

Neuron myelination is critical to early mental development, and defects in myelination have been linked to neurodevelopmental disorders. Researchers a...

2018-2-6

Study reveals genetic basis of quantitative traits and diseases in Japanese

Genome-wide association study reveals genetic basis of quantitative traits and complex biological links

Osaka University-centered researchers presented one of the largest non-European genome-wide association study (GWAS) of quantitative biological traits...

Life Sciences & Medicine
2018-2-2

New genome-editing method “cuts back” on unwanted genetic mutations

Researchers at Osaka University develop novel method that can introduce precise modifications to defective genes with fewer safety drawbacks

Gene therapy can potentially correct genetic disorders by directly editing defective genes. CRISPR-Cas9 is a popular gene-editing technology whose cli...

Life Sciences & Medicine
2018-1-19

New computational method reveals chemoresistance drug targets

Osaka University researchers develop method to extract valuable information from gene expression level and DNA methylation modification data

The methylation of deoxycytosine to form 5-methylcytosine (5mC) is an important feature of cancer. Extensive DNA methylation and transcription analyse...

2018-1-19

Involvement of subcortical regions in social functioning impairment in schizophrenia discovered

Life Sciences & Medicine
2018-1-19

Clarifying the interplay between bone cells in bone remodeling

Osaka University study shows spatiotemporal intercellular interactions between mature osteoblasts and mature osteoclasts in bone homeostasis in vivo

Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOB) and bone-resorptive mature osteoclasts (mOC). However, th...

2018-1-17

Mechanism of familial Parkinson’s disease clarified in fruit fly model

Japanese research collaboration uses fruit flies to show how genetic mutation linked to familial forms of Parkinson’s leads to key events in the disease

Parkinson’s disease (PD) is a common neurodegenerative disorder, in which 15% of cases are linked to genetic mutations. The DNAJC13 gene has been link...

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