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Life Sciences & Medicine
2020-10-12

The making of memory B cells and long-term immune responses

Only B cells that express Bach2 and reduced mTORC1 activity can become memory B cells, the body’s first responder to re-infections

Researchers at Osaka University in Japan have identified two factors necessary for the production of memory B cells, the cells of the immune system th...

Life Sciences & Medicine
2020-8-24

Antibody blockade effective in treatment of severe COVID-19

A team of researchers led by Osaka University find an overlap in the pathogenesis of cytokine release syndrome and COVID-19, and show that the symptoms of both can be alleviated by IL-6 signaling blockade

A hyperinflammatory response following infection or trauma can cause the life-threatening condition cytokine release syndrome (CRS). Researchers led b...

Life Sciences & Medicine
2020-7-13

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

Life Sciences & Medicine
2020-6-23

The protein that stands between us and autoimmunity

Researchers from Osaka University identify the proteins Tet2 and Tet3 as key regulators of B cell activity and autoimmunity

Researchers from Osaka University identified the epigenetic proteins Tet2 and Tet3 as key regulators of B cell function. They showed that these protei...

Life Sciences & Medicine
2020-3-24

It’s in our genome: Uncovering clues to longevity from human genetics

Researchers from Osaka University use genetic and clinical information of 700,000 individuals worldwide to show that high blood pressure and obesity are the strongest risk factors for reduced lifespan in our generation

Researchers from Osaka University found that high blood pressure and obesity are the strongest factors reducing lifespan based on genetic and clinical...

Life Sciences & Medicine
2020-3-18

How tissues harm themselves during wound healing

Researchers from Osaka University identify the protein Rbm7 as a novel regulator of the development of tissue fibrosis

Researchers from Osaka University discovered that increased expression of Rbm7 in apoptotic tissue cells results in the recruitment of segregated-nucl...

Life Sciences & Medicine
2020-1-20

Key to beating colorectal cancer hiding in plain sight?

Researchers led by Osaka University link the well-characterized serine racemase-mediated production of pyruvate from L-serine to colorectal cancer

Colorectal cancer, one of the most common cancers in the developed world, is intrinsically resistant to many drug therapies. In an attempt to identify...

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