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Life Sciences & Medicine
2020-9-29

Lipids, lysosomes, and autophagy: the keys to preventing kidney injury

A team of researchers led by Osaka University unravel a tangle of pathways involving calcium, lipids, and the degradation of damaged lysosomes that is essential for preventing crystal-induced kidney injury

Lysosomes are cellular waste disposal organelles containing potent enzymes that cause cellular damage if they leak out of ruptured lysosomes. In a rec...

Life Sciences & Medicine
2020-8-28

Faulty transportation of messenger RNA is the culprit in ALS

The lack of protein TDP-43 in two neurodegenerative diseases is shown to prevent neuron growth via failed transport of RNA and subsequent absence of protein synthesis in axons

A team including Osaka University researchers has discovered a function for the protein missing in many types of ALS and FTLD, two neurodegenerative d...

Life Sciences & Medicine
2020-8-25

RNA quality control system goes awry in frontotemporal lobar degeneration

Researchers at Osaka University identify vicious cycle involving RNA exosome that accelerates disease progression in FTLD/ALS

Researchers from Osaka University have uncovered that the RNA exosome is critical for the degradation of defective repeat RNA derived from C9orf72 rep...

Life Sciences & Medicine
2020-8-20

Is turning back the clock in aging fat cells a remedy for lifestyle diseases?

Researchers led by Osaka University find that reversing age-related changes in fat cells may prevent the development of lifestyle diseases such as diabetes and fatty liver

Researchers from Osaka University found that lifestyle diseases such as diabetes, high cholesterol, and fatty liver are caused by age-related changes ...

Life Sciences & Medicine
2020-8-1

Change isn’t a good thing for Japanese rheumatoid arthritis patients

Researchers led by Osaka University find that some Japanese rheumatoid arthritis patients are genetically predisposed to interstitial lung disease

Interstitial lung disease (ILD) is a common complication of rheumatoid arthritis (RA) that dramatically increases the risk of death. In a recent study...

Life Sciences & Medicine
2020-7-28

Pathological regression of lymph nodes better predicts esophageal cancer survival

A team of researchers led by Osaka University established a new pathological grading system to evaluate the therapeutic effect of neoadjuvant chemothe...

Life Sciences & Medicine
2020-7-23

A novel tissue imaging system accelerates cancer diagnosis

Researchers from Osaka University develop a novel three-dimensional imaging system to diagnose cervical cancer faster, non-invasively and more efficiently than conventional methods

Researchers from Osaka University developed a novel three-dimensional imaging system to diagnose cervical cancer in a faster, non-invasive and more ef...

Life Sciences & Medicine
2020-7-17

Phantom-limb pain reduced through brain power

In a random crossover trial, researchers at Osaka University were able to reduce phantom-limb pain after only three days of training with a brain-computer-interface

Osaka University researchers have used a brain-computer-interface to reduce phantom-limb pain after only three days of training. In a random crossover...

Life Sciences & Medicine
2020-7-11

Fat cell hormone boosts potential of stem cell therapy

A team of researchers led by Osaka University find that adiponectin, a hormone derived from fat cells, improves the efficacy of mesenchymal stem cell-based treatment of heart failure

Mesenchymal stem cell (MSC) therapy has shown promising results in the treatment of conditions ranging from liver cirrhosis to retinal damage, but res...

Life Sciences & Medicine
2020-7-1

Task force formed to identify genetic clues to COVID-19 susceptibility

Universities and medical institutions in Japan established a task force to examine genes associated with COVID-19 immune response by collecting samples from Japanese patients, aiming to apply their findings to the development of mucosal vaccine

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