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Life Sciences & Medicine
2019-3-11

Winning the Arms Race: Analysis Reveals Key Gene for Bacterial Infection

Researchers at Osaka University use molecular-level analyses of evolution to identify a key gene in bacterial infection, potentially providing a novel target for drugs that could minimize the incidence of bacterial resistance

Researchers at Osaka University applied molecular evolutionary analysis to quantify the severity of negative selection pressures on genes encoding the...

2019-3-7

Tiny DNA Reader to Advance Development of Anticancer Drugs

Researchers from Osaka University use tiny probes and an electrical current to locate anticancer drug molecules incorporated into single strands of DNA

Researchers at Osaka University have developed a novel method to determine exactly where anticancer drug molecules are incorporated into microscopic s...

Life Sciences & Medicine
2019-3-6

Hematopoietic Stem Cells: Making Blood Thicker than Water

Researchers at Osaka University reveal how a regulatory molecule ensures an appropriate supply of blood cells while avoiding the excessive proliferation associated with conditions like leukemia

An Osaka University-led team revealed that Ragnase-1 is a key regulator of the self-renewal and differentiation of hematopoietic stem and progenitor c...

Life Sciences & Medicine
2019-3-1

ECG rhythm and Airway Management Make All the Difference During A Heart Attack

Japan-based study involving Osaka University finds valuable correlation between use of advanced airway management and ECG rhythms indicating need/non-need for defibrillation during out-of-hospital cardiac arrest

Japan-based research examined a large-scale national registry of cardiac arrest cases to measure the effects of advanced airway management (AAM) on 1-...

Life Sciences & Medicine
2019-2-28

Adipocyte glucocorticoid receptors play a role in developing steroid diabetes

Osaka University researchers clarify part of mechanism behind the development of steroid diabetes

Researchers at Osaka University focused on glucocorticoid receptors (GRs), the receptors for the body’s endogenous steroids, clarifying part of the me...

Life Sciences & Medicine
2019-2-22

Treatment to a T? Taking a BiTE Out of Lung Cancer

Researchers at Osaka University reveal a correlation between the activity of T cells in lung cancer tumors and equivalent activity in the blood

An Osaka University-led research team assayed T cell cytotoxicity in tumor tissue in lung cancer, along with normal lung tissue and peripheral blood. ...

Life Sciences & Medicine
2019-2-21

Pumping Iron Could Save Your Life

Researchers from Osaka University find that increased muscle mass improves your chances of responding favorably to cancer treatment

Researchers from Osaka University have found that sarcopenia, a condition characterized by decreased skeletal muscle mass, is strongly associated with...

Life Sciences & Medicine
2019-2-19

The key to increased lifespan? Rubicon alters autophagy in animals during aging

Osaka University-led study shows that increased expression of Rubicon in tissues from aged animals contributed to reduced levels of autophagy, which may lead to aging progression

Autophagy is an important biological recycling mechanism that influences the progression of aging in animals. Here, age-related changes in autophagy w...

Life Sciences & Medicine
2019-2-7

When Good Cells Go Bad: Regulating the MS-Causing Properties of Th17 Cells

Researchers identify a protein regulator responsible for inducing the pathogenic properties of Th17 cells, leading to multiple sclerosis and other inflammatory autoimmune disorders

Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain...

Life Sciences & Medicine
2019-2-6

More Physical Than Chemical: Researchers Show What Really Gets Cells Going

A team led by researchers from Osaka University find that unlike their unicellular counterparts, aggregated social amoebae need physical contact rather than chemical signals to get them going

Collective cell migration is essential in many organisms, with roles in human cellular processes including cancer invasion and wound healing. Now, a t...

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