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Life Sciences & Medicine

Adipocyte glucocorticoid receptors play a role in developing steroid diabetes

Osaka University researchers clarify part of mechanism behind the development of steroid diabetes

Researchers at Osaka University focused on glucocorticoid receptors (GRs), the receptors for the body’s endogenous steroids, clarifying part of the me...

Life Sciences & Medicine

Treatment to a T? Taking a BiTE Out of Lung Cancer

Researchers at Osaka University reveal a correlation between the activity of T cells in lung cancer tumors and equivalent activity in the blood

An Osaka University-led research team assayed T cell cytotoxicity in tumor tissue in lung cancer, along with normal lung tissue and peripheral blood. ...

Life Sciences & Medicine

Pumping Iron Could Save Your Life

Researchers from Osaka University find that increased muscle mass improves your chances of responding favorably to cancer treatment

Researchers from Osaka University have found that sarcopenia, a condition characterized by decreased skeletal muscle mass, is strongly associated with...

Life Sciences & Medicine

The key to increased lifespan? Rubicon alters autophagy in animals during aging

Osaka University-led study shows that increased expression of Rubicon in tissues from aged animals contributed to reduced levels of autophagy, which may lead to aging progression

Autophagy is an important biological recycling mechanism that influences the progression of aging in animals. Here, age-related changes in autophagy w...

Life Sciences & Medicine

When Good Cells Go Bad: Regulating the MS-Causing Properties of Th17 Cells

Researchers identify a protein regulator responsible for inducing the pathogenic properties of Th17 cells, leading to multiple sclerosis and other inflammatory autoimmune disorders

Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain...

Life Sciences & Medicine

Large-scale Study Reveals Genetic Risk of Diabetes in the Japanese Population

Researchers have combined data from genetic studies and revealed 28 new genomic regions associated with type 2 diabetes, some variants of which are not found in other ethnic groups

Researchers at Osaka University, The University of Tokyo, RIKEN, and others performed a meta-analysis using data on over 36,000 Japanese sufferers of ...

Life Sciences & Medicine

Japanese Study Finds Concerning Trends in Cervical Cancer and Treatment Response

Osaka University-centered study examines large-scale population survey and identifies increase in cervical cancer rate, along with younger patients’ surprising resistance to radiation therapy

Osaka University-centered research examined a large-scale Japanese data cohort for trends in cervical cancer prevalence, treatment, and survival. They...

Life Sciences & Medicine

Big Data Provides Clues for Characterizing Immunity in Japanese

An Osaka University-centered research team has performed fine-mapping of the key immunity-related part of the genome, revealing associations between gene variants and over 50 different phenotypes in the Japanese

Osaka University researchers used various sets of large-scale data to characterize the variation and phenotypic associations of an immunity-related ge...

Life Sciences & Medicine

Small Metabolites Have Big Effects on the Intestinal Immune Response

Researchers at Osaka University find that common bacterial metabolites pyruvate and lactate enhance the intestinal immune response and guard against infection by important gut pathogens

Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cau...

Life Sciences & Medicine

Therapeutic and Diagnostic Functions of One Antibody for Pancreatic Cancer

Osaka University researchers base biomarker detection and targeted therapy on the same protein from pancreatic cancer patients

Osaka University researchers developed monoclonal antibodies against CKAP4—a plasma membrane protein—and found that it was released from pancreatic ca...


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