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Life Sciences & Medicine
2018-11-19

Getting things under control: new mouse model aids study of immunomodulation

Osaka University-led research team has generated a novel mouse model to study complex mechanisms of immunomodulatory human disease therapies that are ineffective in wild-type mice

Mice are resistant to immunomodulatory drugs (IMiDs). As a result, studying the effects of IMiDs was not possible in existing types of mice. Here, an ...

Life Sciences & Medicine
2018-10-23

The Mincle receptor provides protective immunity against Group A Streptococcus

Osaka University-led study shows that Mincle initiates antibacterial response to Group A Streptococcus upon recognition of MGDG, an anchor of lipoteichoic acid

Group A Streptococcus (GAS) causes invasive infections that result in high mortality. Despite being susceptible to many antibiotics, GAS continues to ...

Life Sciences & Medicine
2018-8-29

Dectin-1-mediated pain is critical for the resolution of fungal inflammation

Osaka University study shows that the Dectin-1 to TRP channel pathway is a novel signaling mechanism in the onset of pain, and that inhibition of the VNUT ATP transporter blocks candidiasis-mediated pain

Candidiasis is a painful infection that affects a large number of individuals, occasionally causing severe pain that is solely controlled by resolutio...

Life Sciences & Medicine
2018-5-23

Igniting the Rheumatoid Arthritis Flame Through A Cellular Cascade

Osaka University-led researchers identify cellular network that secretes inflammatory cytokines to initiate and maintain rheumatoid arthritis

Osaka University-led international researchers identified a network of cells responsible for secretion of a key inflammatory cytokine in development o...

Life Sciences & Medicine
2018-4-18

Accepted or Rejected? Uncovering How Fate of B Cell is Determined

Osaka University-centered researchers elucidate the mechanisms of B cell differentiation in the germinal center

Osaka University-centered researchers identify the plasma cell-prone B cells in the light zone of germinal centers. Higher expression of the proteins ...

Life Sciences & Medicine
2018-3-6

Multiple optical measurements reveal the single cell activation without contrast agent

Life Sciences & Medicine
2018-3-6

Helpful B cells lend a hand to developing neurons

Researchers at Osaka University identify an immune cell that promotes the growth of neuron-supporting cells in the developing mouse brain

Neuron myelination is critical to early mental development, and defects in myelination have been linked to neurodevelopmental disorders. Researchers a...

Life Sciences & Medicine
2018-1-9

Efficacy of antibody targeting Devic’s disease proven in new animal model

Osaka University study identifies antibody that alleviates symptoms in neuromyelitis optica in rats

Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG). A cure for NMO remains elusive. Osaka University r...

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