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Life Sciences & Medicine
2018-4-4

New light shed on how bone marrow niches keep stem cells thriving

Japanese researchers uncover cellular factor needed to maintain the environment that regulates hematopoietic stem cells

Hematopoietic stem cells (HSCs) require specialized niches in bone marrow to generate functional blood cells. CAR cells are among cell types located i...

Life Sciences & Medicine
2018-3-30

Even short travel can spread colistin-resistant bacteria

Japanese researchers find short trips to a developing country can increase the appearance of a resistance gene to the antibiotic colistin

The use of the antibiotic colistin, a last-resort treatment option in the infection by multidrug-resistant bacteria, is increasingly impeded by colist...

Life Sciences & Medicine
2018-3-29

Formidable duo: protective effect of CD9 and CD81 in COPD and accelerated aging

Osaka University-centered study reveals double deletion of tetraspanins CD9 and CD81 in mice cause progressive aging and shortened life span

Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, but the mechanism remains unclear. Osaka University-centered rese...

Life Sciences & Medicine
2018-3-26

New Breakthrough in Treatment for Rare Skin Condition

Drug to treat skin lesions in tuberous sclerosis complex approved, a world first

Life Sciences & Medicine
2018-3-20

Cholesterol leash: key tethering protein found to transport cellular cholesterol

Researchers at Osaka University uncover key mechanistic details that allow cholesterol to be transported within cells

Cholesterol is an essential component of living organisms, but the mechanisms that transport cholesterol inside the cell are poorly understood. Resear...

2018-3-13

Strength in numbers: Worldwide study finds new genetic risk factors for stroke

Researchers in a large multicenter study develop a comprehensive map of genetic risk factors for stroke and lay the groundwork for more individualized approaches to treatment

Stroke is the second leading cause of death worldwide, but its genetic basis is unknown. In a large, multicenter effort, researchers performed a genom...

Life Sciences & Medicine
2018-3-9

Genome does not like to excessively change in male germ cells

Life Sciences & Medicine
2018-3-6

Helpful B cells lend a hand to developing neurons

Researchers at Osaka University identify an immune cell that promotes the growth of neuron-supporting cells in the developing mouse brain

Neuron myelination is critical to early mental development, and defects in myelination have been linked to neurodevelopmental disorders. Researchers a...

2018-2-6

Study reveals genetic basis of quantitative traits and diseases in Japanese

Genome-wide association study reveals genetic basis of quantitative traits and complex biological links

Osaka University-centered researchers presented one of the largest non-European genome-wide association study (GWAS) of quantitative biological traits...

Life Sciences & Medicine
2018-2-2

New genome-editing method “cuts back” on unwanted genetic mutations

Researchers at Osaka University develop novel method that can introduce precise modifications to defective genes with fewer safety drawbacks

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