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Life Sciences & Medicine
2018-11-22

Gip1 structure places G proteins in lockdown

Researchers show that the protein Gip1 possesses a cylinder-like fold with a central hydrophobic cavity, which forms a complex with heterotrimeric G proteins and inhibits downstream signal transduction

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which is important in the detection of various stimuli. Here, an Osak...

2018-11-19

Cause of variability in human stereoacuity clarified

Will help improve the ability to discriminate depth

Life Sciences & Medicine
2018-11-13

Pulling the Genome Apart: Chromosome Segregation During Mitosis Explained

Researchers reveal the importance of a pathway in controlling the segregation of chromosomes when cells divide, which could be useful for treating a range of diseases associated with abnormal cell division

Osaka University researchers shed light on the protein complexes and processes that enable microtubules to bind to the centromeres of chromosomes and ...

2018-10-30

Molecular Inhibition Gets Cells on the Move

Researchers at Osaka University show how the mutual inhibition of two molecules results in their localization at opposite ends of cells, acting as a trigger for the formation of appendages at one cell end that makes directional cell movement possible

Osaka University researchers revealed that two molecules, PTEN and PIP3, mutually inhibit each other to ensure their exclusive distribution at opposit...

2018-9-26

Artificial Intelligence Aids Automatic Monitoring of Single Molecules in Cells

Japanese researchers have developed an automated method of tracking single fluorescently labeled molecules in living cells, enabling large numbers of molecules to be analyzed and characterized rapidly and cost-effectively

Japanese researchers developed a system that can automatically image single molecules within living cells. This system employs learning via neural net...

Natural Sciences
2018-8-30

Mystery of circles on the sea bed uncovered

New pufferfish found to be the geometric circle creator on the sea bottom

Life Sciences & Medicine
2018-7-6

Who made the error? - The brain distinguishes causes of errors to perform adaptation

Osaka University scientists clarify how the brain drives trial-by-trial adaptation to compensate for errors by differentiating the cause of error

Osaka University scientists examined positions to detect motor and target errors and whether error signals from these positions were used for learning...

Life Sciences & Medicine
2018-6-27

Key Protein Providing Defense Against “Jumping Genes” Identified

International study illuminates intricate piRNA pathway and transposon repression

International researchers revealed the crucial function of the protein HP1a for piRNA biogenesis, which is important for transposon silencing. Transpo...

Life Sciences & Medicine
2018-4-27

How do cells sense glutamine and control their autophagy and activation?

Glutamine-dependent activation of cell growth discovered

Scientists at Osaka University clarified that the Pib2 complex directly bound to glutamine in yeast cells, which activated a signaling pathway for cel...

Life Sciences & Medicine
2018-4-26

Study sheds light on bacterial propeller assembly

Japanese researchers propose a model for how the parts of a bacterial flagellum are assembled

The bacterial flagellum is a motor whose assembly occurs in an ordered, stepwise fashion. However, the molecular details of this ordered assembly are ...

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