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2018-4-9

Insulin is a hormone made by the pancreas and helps cells to take in glucose from the blood. Insulin binds to insulin receptors to activate Insulin Receptor Substrate 1 (IRS-1), taking in sugar through phosphorylation of Akt. If insulin loses its effectiveness, a bulk of the cells in the body becomes unable to take up glucose and high blood sugar levels persist, leading to diabetes.

A group of researchers led by Atsunori Fukuhara has reported that adipocytokine, or cell signaling proteins secreted by the adipose tissue, played a role in developing obesity. However, it was not known that adipocytokine activated on adipocytes themselves to control insulin sensitivity. SDF-1, one of the adipocytokines, is the most predominantly expressed chemokine; however, its action on glucose uptake in cells had not been analyzed.

Using microarray database analysis, this group of scientists identified SDF-1 as a factor to enhance expression in adipocytes in both fasting and obese states and found that SDF-1 reduced the effectiveness of insulin in adipocytes. In actuality, in SDF-1 knockout mice, insulin-induced glucose uptake increased (i.e., blood sugar levels decreased), and insulin efficacy improved (i.e., insulin sensitivity was enhanced). Their research results were published in Diabetes.

Based on the results of this study, it is expected that insulin sensitivity in adipocytes will increase by inactivating the SDF-1 signaling pathway, which will lead to treatment of obese type 2 diabetes.

Fig.1.
(credit: Osaka University)
1) Fasting or obesity induces SDF-1 expression in adipocytes. 2) Its autocrine action activates ERK signaling. 3) SDF-1–induced ERK signal concomitantly induces serine phosphorylation of IRS-1 protein, and degrades IRS-1 protein. This attenuates 4) insulin-mediated Akt phosphorylation and 5) glucose uptake.

To learn more about this research, please view the full research report entitled "SDF-1 is an autocrine insulin-desensitizing factor in adipocytes" at this page of Diabetes.


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