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Efflux pump inhibitors: Bulking up to beat bacteria
Researchers from Osaka University used a combination of genetic manipulation and protein structural analysis to determine how the position of “bulky” amino ...
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2022
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Schematic diagrams showing the roles of SNAP23 in pancreatic β cells
A group of researchers generated pancreatic exocrine- or endocrine-specific SNAP23 knockout mice to investigate the in vivo function of SNAP23 and found that ...
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2016
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Role of Molecular Modification in Determining Physical Activity Levels Revealed
Osaka University-led researchers showed that RNA editing of the molecule CAPS1 is associated with increased dense core vesicle exocytosis, the mechanism by ...
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2016
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High-resolution pH Imaging Elucidates Energy Mechanisms in Creating Bacterial Flagella
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2016
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Breakdown of Neutrophil Protein Causes Severe Autoimmune Disease of Blood Vessels
Osaka University researchers revealed that patients with a severe autoimmune disease that attacks the blood vessels lack the membrane form of a protein ...
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2017
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Important Tricyclic Chemical Compounds with Efficient Chirality Control
Research team of Osaka University synthesized hydronaphtho[1,8-bc]furans, important chiral building blocks for natural-product synthesis. They used a nickel ...
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2017
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Osaka University Chemists Unlock the Potential of Fluoroalkenes
Osaka University-led chemists developed a copper-catalyzed reaction for replacing fluorine atoms with an easily transformable boronate group on polyfluorinated ...
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2017
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Pathological Mechanisms in Congenital Myotonic Dystrophy Unveiled
Congenital myotonic dystrophy (CDM) is a severe form of myotonic dystrophy characterized by muscle fiber immaturity not observed in adult DM, suggesting ...
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2017
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How Bacteria Get Their Groove: Mechanism behind Flagellar Motility
Most motile bacteria move by the use of flagella. While the flagellar motor components have been identified, it remains unclear how they are assembled and ...
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2017
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New Strategy for Multiple Myeloma Immunotherapy
Cancer-specific proteins have been identified for the development of monoclonal antibody (mA)-based therapies, but there remains a need to uncover new targets, ...
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2017