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Cholesterol leash: key tethering protein found to transport cellular cholesterol

Cholesterol is an essential component of living organisms, but the mechanisms that transport cholesterol inside the cell are poorly understood. Resear...

Genome does not like to excessively change in male germ cells

Researchers find adult endothelial stem cells that can make fully functional blood vessels

Stem cells are increasingly used to treat disorders caused by defective tissues. The repair of blood vessels by vascular endothelial stem cells (VESCs...

Study reveals genetic basis of quantitative traits and diseases in Japanese

Osaka University-centered researchers presented one of the largest non-European genome-wide association study (GWAS) of quantitative biological traits...

New genome-editing method “cuts back” on unwanted genetic mutations

Gene therapy can potentially correct genetic disorders by directly editing defective genes. CRISPR-Cas9 is a popular gene-editing technology whose cli...

Magnesium makes chromosomes

New computational method reveals chemoresistance drug targets

The methylation of deoxycytosine to form 5-methylcytosine (5mC) is an important feature of cancer. Extensive DNA methylation and transcription analyse...

Clarifying the interplay between bone cells in bone remodeling

Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOB) and bone-resorptive mature osteoclasts (mOC). However, th...

Mechanism of familial Parkinson’s disease clarified in fruit fly model

Parkinson’s disease (PD) is a common neurodegenerative disorder, in which 15% of cases are linked to genetic mutations. The DNAJC13 gene has been link...

Snapshot of DNA repair

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