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Is turning back the clock in aging fat cells a remedy for lifestyle diseases?
Researchers from Osaka University found that lifestyle diseases such as diabetes, high cholesterol, and fatty liver are caused by age-related changes in fat ...
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2020
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Lipids, lysosomes, and autophagy: the keys to preventing kidney injury
Lysosomes are cellular waste disposal organelles containing potent enzymes that cause cellular damage if they leak out of ruptured lysosomes. In a recent study ...
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2020
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Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth
Researchers led by Osaka University have found that liver cancer cells induce autophagy in hepatic stellate cells, causing them to produce a growth factor ...
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2020
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Lowering blood insulin levels could lower your risk of getting COVID-19
Researchers from Osaka University have found that the SARS-CoV-2 spike protein binds directly to GRP78, which is expressed at high levels in adipose tissue and ...
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2021
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Meet the Smurfs: A bone metabolism family
Researchers from Osaka University and Ehime University have found that protein Smurf2 can regulate a cellular pathway that affects bone metabolism. Smurf2 can ...
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2020
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Modeling the human eye in a dish
Researchers from Osaka University developed and validated a novel PITX2-eGFP hiPSC reporter line to model the development of periocular mesenchymal cells. ...
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2020
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My heart will go on: patient-derived heart cells mimic disease in vitro
Researchers from Osaka University have found that induced pluripotent stem cell–derived cardiomyocytes from a patient with arrhythmogenic cardiomyopathy ...
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2022
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Newly discovered enzyme helps make valuable bioactive saponins
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2020
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No more aggravation: ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis
Osaka University researchers identified a mechanism underlying prevention of microbial metabolite-induced colitis. A protein called E-NTPD8 breaks down ATP ...
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2021
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Researchers find an explanation of why pancreatic cancer cells are so aggressive
Researchers from Osaka University have found a novel mechanism linked to the aggressiveness of pancreatic cancer, one of the leading causes of cancer death. ...
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2021
