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Reading the Signs: Semaphorin Linked to Lung Cancer Treatment Resistance
Osaka University researchers showed that high levels of the protein Semaphorin 7a are associated with resistance to treatment with EGFR-TKIs in lung ...
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2018
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Designing antibody medicines using alanine substitutions
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2019
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Keeping Chromosomes in Check: A New Role for Heterochromatin
Large changes in the structure of chromosomes are usually fatal for the cell or can lead to genetic diseases such as cancer. Many large chromosomal ...
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2019
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Therapeutic and Diagnostic Functions of One Antibody for Pancreatic Cancer
Osaka University researchers developed monoclonal antibodies against CKAP4—a plasma membrane protein—and found that it was released from pancreatic cancer ...
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2019
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Small Metabolites Have Big Effects on the Intestinal Immune Response
Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause ...
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2019
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Big Data Provides Clues for Characterizing Immunity in Japanese
Osaka University researchers used various sets of large-scale data to characterize the variation and phenotypic associations of an immunity-related gene region ...
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2019
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Large-scale Study Reveals Genetic Risk of Diabetes in the Japanese Population
Researchers at Osaka University, The University of Tokyo, RIKEN, and others performed a meta-analysis using data on over 36,000 Japanese sufferers of type 2 ...
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2019
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More Physical Than Chemical: Researchers Show What Really Gets Cells Going
Collective cell migration is essential in many organisms, with roles in human cellular processes including cancer invasion and wound healing. Now, a team led ...
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2019
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When Good Cells Go Bad: Regulating the MS-Causing Properties of Th17 Cells
Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a ...
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2019
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Treatment to a T? Taking a BiTE Out of Lung Cancer
An Osaka University-led research team assayed T cell cytotoxicity in tumor tissue in lung cancer, along with normal lung tissue and peripheral blood. They ...
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2019
