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A lipid makes lymphocytes move swiftly within lymph nodes
A group at Osaka University has found for the first time that a lipid called lysophosphatidic acid (LPA) plays a vital role in regulating lymphocyte motility ...
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2016
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Accepted or Rejected? Uncovering How Fate of B Cell is Determined
Osaka University-centered researchers identify the plasma cell-prone B cells in the light zone of germinal centers. Higher expression of the proteins ICAM-1 ...
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2018
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Big Data Provides Clues for Characterizing Immunity in Japanese
Osaka University researchers used various sets of large-scale data to characterize the variation and phenotypic associations of an immunity-related gene region ...
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2019
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Brain cancer potentially resists immunotherapies by trapping T cells in bone marrow
Researchers in collaboration with Osaka University found that brain tumors in mice and humans cause immune T-cells to become trapped in bone marrow. This ...
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2018
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CD4 T Cells, Xenobiotic Transporters, and Metabolites in Inflammatory Bowel Diseases
Few studies have investigated the interaction between intestinal T cells with metabolites. Researchers have now shown in mice CD4+ T effector (Teff) cells ...
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2017
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Discovery of key molecules involved in severe malaria
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2017
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Efficacy of antibody targeting Devic’s disease proven in new animal model
Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG). A cure for NMO remains elusive. Osaka University ...
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2018
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Helpful B cells lend a hand to developing neurons
Neuron myelination is critical to early mental development, and defects in myelination have been linked to neurodevelopmental disorders. Researchers at Osaka ...
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2018
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High immunoscores may help some win the battle against cancer
Osaka University researchers determined that the number of tumor-infiltrating lymphocytes (TILs) present in esophageal cancer tumors correlated with patient ...
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2021
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How hepatitis C virus evades the immune system
Researchers from Osaka University unpicked how hepatitis C virus (HCV) and human cytomegalovirus (HCMV) evade the immune system to cause chronic infection. By ...
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2021