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The making of memory B cells and long-term immune responses
Researchers at Osaka University in Japan have identified two factors necessary for the production of memory B cells, the cells of the immune system that allow ...
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2020
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Antibody blockade effective in treatment of severe COVID-19
A hyperinflammatory response following infection or trauma can cause the life-threatening condition cytokine release syndrome (CRS). Researchers led by Osaka ...
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2020
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Change isn’t a good thing for Japanese rheumatoid arthritis patients
Interstitial lung disease (ILD) is a common complication of rheumatoid arthritis (RA) that dramatically increases the risk of death. In a recent study led by ...
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2020
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A new approach to calm that angry nose
Eosinophilic chronic rhinosinusitis (ECRS) is a type of airway disease that involves nasal inflammation. Here, semaphorin protein was found to contribute to ...
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2020
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When your microbiome and your genome aren’t a good combination
Research carried out by a team led by Osaka University has shown that various Prevotella species, along with several specific genes and biological pathways, ...
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2019
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Phosphorylation of Regnase-1 Lets IL-17 Run Amok
A research team led by Osaka University found that the cytokine interleukin (IL)-17 triggers the phosphorylation of mRNA-degrading enzyme Regnase-1, resulting ...
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2019
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When Good Cells Go Bad: Regulating the MS-Causing Properties of Th17 Cells
Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a ...
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2019
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Small Metabolites Have Big Effects on the Intestinal Immune Response
Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause ...
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2019
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Resist! TAK1 enables endothelial cells to avoid apoptosis
TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in ...
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2019
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Lung Neuropeptide Exacerbates Lethal Influenza Virus Infection
Researchers found that lung immune cells (phagocytes) produce increased levels of neuropeptide Y (NPY) when mice are infected with severe influenza virus. NPY ...
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2018