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  1. The making of memory B cells and long-term immune responses

    Researchers at Osaka University in Japan have identified two factors necessary for the production of memory B cells, the cells of the immune system that allow ...

    Located in Research Info / 2020
  2. Antibody blockade effective in treatment of severe COVID-19

    A hyperinflammatory response following infection or trauma can cause the life-threatening condition cytokine release syndrome (CRS). Researchers led by Osaka ...

    Located in Research Info / 2020
  3. Change isn’t a good thing for Japanese rheumatoid arthritis patients

    Interstitial lung disease (ILD) is a common complication of rheumatoid arthritis (RA) that dramatically increases the risk of death. In a recent study led by ...

    Located in Research Info / 2020
  4. A new approach to calm that angry nose

    Eosinophilic chronic rhinosinusitis (ECRS) is a type of airway disease that involves nasal inflammation. Here, semaphorin protein was found to contribute to ...

    Located in Research Info / 2020
  5. When your microbiome and your genome aren’t a good combination

    Research carried out by a team led by Osaka University has shown that various Prevotella species, along with several specific genes and biological pathways, ...

    Located in Research Info / 2019
  6. Phosphorylation of Regnase-1 Lets IL-17 Run Amok

    A research team led by Osaka University found that the cytokine interleukin (IL)-17 triggers the phosphorylation of mRNA-degrading enzyme Regnase-1, resulting ...

    Located in Research Info / 2019
  7. When Good Cells Go Bad: Regulating the MS-Causing Properties of Th17 Cells

    Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a ...

    Located in Research Info / 2019
  8. Small Metabolites Have Big Effects on the Intestinal Immune Response

    Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause ...

    Located in Research Info / 2019
  9. Resist! TAK1 enables endothelial cells to avoid apoptosis

    TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in ...

    Located in Research Info / 2019
  10. Lung Neuropeptide Exacerbates Lethal Influenza Virus Infection

    Researchers found that lung immune cells (phagocytes) produce increased levels of neuropeptide Y (NPY) when mice are infected with severe influenza virus. NPY ...

    Located in Research Info / 2018
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