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Breakdown of Neutrophil Protein Causes Severe Autoimmune Disease of Blood Vessels
Osaka University researchers revealed that patients with a severe autoimmune disease that attacks the blood vessels lack the membrane form of a protein ...
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2017
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The Mincle receptor provides protective immunity against Group A Streptococcus
Group A Streptococcus (GAS) causes invasive infections that result in high mortality. Despite being susceptible to many antibiotics, GAS continues to cause ...
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2018
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Getting things under control: new mouse model aids study of immunomodulation
Mice are resistant to immunomodulatory drugs (IMiDs). As a result, studying the effects of IMiDs was not possible in existing types of mice. Here, an Osaka ...
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2018
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Going viral: New cells for norovirus production in the lab
Human norovirus is a major cause of infections that can be particularly dangerous to children and elderly people. Here, an Osaka University-led research team ...
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2018
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Lung Neuropeptide Exacerbates Lethal Influenza Virus Infection
Researchers found that lung immune cells (phagocytes) produce increased levels of neuropeptide Y (NPY) when mice are infected with severe influenza virus. NPY ...
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2018
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How low can we go? Nanopore detection of single flu viruses to control outbreaks
Influenza is a highly contagious respiratory disease that may cause a serious outbreak at any time. Here, an Osaka University-led research team developed a new ...
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2018
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Dectin-1-mediated pain is critical for the resolution of fungal inflammation
Candidiasis is a painful infection that affects a large number of individuals, occasionally causing severe pain that is solely controlled by resolution of ...
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2018
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Resist! TAK1 enables endothelial cells to avoid apoptosis
TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in ...
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2019
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Small Metabolites Have Big Effects on the Intestinal Immune Response
Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause ...
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2019
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When Good Cells Go Bad: Regulating the MS-Causing Properties of Th17 Cells
Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a ...
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2019
