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Osaka University researchers revealed that two molecules, PTEN and PIP3, mutually inhibit each other to ensure their exclusive distribution at opposite ends of ...

Collective cell migration is essential in many organisms, with roles in human cellular processes including cancer invasion and wound healing. Now, a team led ...

Neuropathic pain is a chronic condition resulting from nerve injury and is characterized by increased pain sensitivity. Although known to be associated with ...

The methylation of deoxycytosine to form 5-methylcytosine (5mC) is an important feature of cancer. Extensive DNA methylation and transcription analyses have ...

Gene therapy can potentially correct genetic disorders by directly editing defective genes. CRISPR-Cas9 is a popular gene-editing technology whose clinical ...

Osaka University researchers developed a novel method of identifying disease-related molecules and processes. They achieved this by integrating genetic data ...

Hematopoietic stem cells (HSCs) require specialized niches in bone marrow to generate functional blood cells. CAR cells are among cell types located in niches, ...

The more than 200 species of nontuberculous mycobacteria (NTM) are notoriously difficult to differentiate, delaying the implementation of targeted antibiotic ...

A group of researchers developed two new gene modification methods: lsODN and 2H2OP. These methods will increase the efficiency of genetic engineering in mice ...

Cancer-specific proteins have been identified for the development of monoclonal antibody (mA)-based therapies, but there remains a need to uncover new targets, ...