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A lipid makes lymphocytes move swiftly within lymph nodes
A group at Osaka University has found for the first time that a lipid called lysophosphatidic acid (LPA) plays a vital role in regulating lymphocyte motility ...
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2016
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Immune responses against pathogens are efficiently induced through cytosolic distribution of interferon-inducible guanylate binding proteins
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2017
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Novel Small Antibody Fragment: A Valuable Tool in Crystallography
Achieving quality diffracting crystals remains the major bottleneck in macromolecular x-ray crystallography. Antibody fragments have been used to aid ...
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2017
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New Strategy for Multiple Myeloma Immunotherapy
Cancer-specific proteins have been identified for the development of monoclonal antibody (mA)-based therapies, but there remains a need to uncover new targets, ...
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2017
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Discovery of key molecules involved in severe malaria
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2017
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CD4 T Cells, Xenobiotic Transporters, and Metabolites in Inflammatory Bowel Diseases
Few studies have investigated the interaction between intestinal T cells with metabolites. Researchers have now shown in mice CD4+ T effector (Teff) cells ...
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2017
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Efficacy of antibody targeting Devic’s disease proven in new animal model
Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG). A cure for NMO remains elusive. Osaka University ...
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2018
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Helpful B cells lend a hand to developing neurons
Neuron myelination is critical to early mental development, and defects in myelination have been linked to neurodevelopmental disorders. Researchers at Osaka ...
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2018
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Accepted or Rejected? Uncovering How Fate of B Cell is Determined
Osaka University-centered researchers identify the plasma cell-prone B cells in the light zone of germinal centers. Higher expression of the proteins ICAM-1 ...
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2018
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Neuron guidance factor found to play a key role in immune cell function
Macrophages are white blood cells that perform different functions with different energy needs. M2-type macrophages have anti-inflammatory properties that may ...
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2018
