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Pathological Mechanisms in Congenital Myotonic Dystrophy Unveiled
Congenital myotonic dystrophy (CDM) is a severe form of myotonic dystrophy characterized by muscle fiber immaturity not observed in adult DM, suggesting ...
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2017
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Phosphorylation of Regnase-1 Lets IL-17 Run Amok
A research team led by Osaka University found that the cytokine interleukin (IL)-17 triggers the phosphorylation of mRNA-degrading enzyme Regnase-1, resulting ...
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2019
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Pulling the Genome Apart: Chromosome Segregation During Mitosis Explained
Osaka University researchers shed light on the protein complexes and processes that enable microtubules to bind to the centromeres of chromosomes and ...
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2018
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Reading the Signs: Semaphorin Linked to Lung Cancer Treatment Resistance
Osaka University researchers showed that high levels of the protein Semaphorin 7a are associated with resistance to treatment with EGFR-TKIs in lung ...
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2018
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Recovering Lost Skeletal Muscle Function by Using Light Pulses
A group of researchers developed photosensitive muscle cells by integrating altered light-responsive ion channels (channelrhodopsin) into myoblasts. This ...
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2015
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Regulator of Chromosome Structure Crucial to Healthy Brain Function and Nerve Development
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2017
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Researchers discover key mechanism of DNA replication
Researchers from Osaka University in Japan have uncovered a key control mechanism of DNA replication with potential implications for better understanding how ...
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2018
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Researchers discover molecular light switch in photoreceptor cells
Transducin, a protein found inside photoreceptor cells in vertebrate eyes, alters its cellular location in response to changes in light intensity, allowing our ...
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2019
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Researchers find adult endothelial stem cells that can make fully functional blood vessels
Stem cells are increasingly used to treat disorders caused by defective tissues. The repair of blood vessels by vascular endothelial stem cells (VESCs) is an ...
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2018
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Researchers split the “AtoM” in search of a treatment for rheumatoid arthritis
Rheumatoid arthritis is a chronic, disabling disease in which the joints become swollen and painfully inflamed. Current treatments can only reduce symptoms or ...
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2019