Synchronous Movement of Transplanted iPS Cells and  Heart Demonstrated at the Molecular Level

Synchronous Movement of Transplanted iPS Cells and Heart Demonstrated at the Molecular Level

Next step towards the realization of regenerative therapy of cardiac muscles through iPS cells

Jan 26, 2015

Evidence of synchronised contraction of infarct heart and transplanted iPS cell-derived cardiac myocytes: An important progress toward clinical study of cardiac regeneration therapy using iPS cells.

  • Yoshiki Sawa , MD, PhD, Division of Cardiovascular Surgery, Graduate School of Medicine, Osaka University
  • Mikiyasu Shirai , PhD, Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute


  • Naoto Yagi , PhD, SPring-8/ Japan Synchrotron Radiation Research Institute

Cardiac regeneration therapy using iPS cells has been reported to be promising as the next generation treatment for advanced cardiac failure. It is however critical to uncover mechanisms underpinning therapeutic effects prior to clinical study of iPS cell-therapy. This basic study using synchrotron radiation from a third generation facility showed that contractile molecules, such as actin and myosin, in the transplanted iPS cell-derived cardiomyocytes synchronised with the native cardiac contraction in murine, by collaboration with Dr. Mikiyasu Shirai, National Cerebral and Cardiovascular Centre Research Institute and Dr. Naoto Yagi, Spring-8/JASRI, Japan. This scientific evidence clarified by Japanese technologies will largely contribute to clinical realization of cardiac regeneration therapy for cardiac disease.

This study was e-published as an original article by Cell Transplantation in Jan 2015.
doi: 10.3727/096368914X685799

This research was supported by the Research Center Network for Realization of Regenerative Medicine managed by Centers for Clinical Application Research on Specific Disease/Organ and funded by Japan Science and Technology Agency, and the International Synchrotron Access Programme (IA111) managed by the Australian Synchrotron and funded by the Australian Government.

For more information, please contact :

  • Division of Cardiovascular Surgery, Graduate School of Medicine, Osaka University -- Tel:+81-(0)6-6879-3154
  • Public Relations Section, National Cerebral and Cardiovascular Research Center -- Tel:+81-(0)6-6833-5012
  • Communications and Outreach Section, Japan Synchrotron Radiation Research Institute -- Tel:+81-(0)791-58-2785

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