Clarification of mechanisms employed by negative costimulatory receptor PD-1 in modulating T cell immune response

Clarification of mechanisms employed by negative costimulatory receptor PD-1 in modulating T cell immune response

These findings may lead to new therapeutic procedures

May 28, 2012

Under the leadership of group leader SAITO Takashi (Professor, WPI Immunology Frontier Research Center [iFReC]), a group lead by YOKOSUKA Tadashi (Researcher, Osaka University and also RIKEN Research Center for Allergy and Immunology, Yokohama) of 3 other outside researchers succeeding in clarifying mechanisms by which programmed cell death (PD-1), a negative costimulatory receptor, tempers T cell response. By elucidating the complex PD-1 mechanism (which also involves the formation of microclusters) their findings hold promise for new therapeutic strategies.

20120528_1_fig1.png

Figure 1

20120528_1_fig2.png

Figure 2

20120528_1_fig3.png

Figure 3

20120528_1_fig4.png

Figure 4

20120528_1_fig5.png

Figure 5

For more information, please view the full report of their research at this page of The Journal of Experimental Medicine .

Related Link:

Technical Glossary